中国骨与关节杂志

    In the 1950s, operation was introduced to treat osteosarcoma in China which could be seen as the beginning of the treatment of osteosarcoma. In 1970’s, Jaffe began to use high-dose methotrexate and leucovorin (MTX-CF) in the treatment of lung metastasis of osteosarcoma, marking the beginning of adjuvant chemotherapy for osteosarcoma. Since then, Rosen designed a preoperative chemotherapy which was considered as neoadjuvant chemotherapy. China developed a suitable chemotherapy for osteosarcoma in 1980’s. Therefore, the chemotherapy for osteosarcoma in China kept pace with the world.